In recent years, economists have come to recognize the role of technology, as well as information, innovation, and creativity, in expanding economic potential towards sustainble development. An innovative economy that is driven by knowledge, creativity, technology, and anchored in strong values will help build resilience in small island developing states (SIDS). The aim of this research is to contribute with knowledge towards the innovative development on small island states, specifically Aruba, considering its socio-economic circumstances and necessity to catch up to other developed countries. The main research question is: “How can a synergy between the creative industry and a knowledge-based economy, implemented within a Quadruple Helix Innovation Model to stimulate sustainable socio-economic development in the local innovation system of Aruba?”. This research is conducted as a case study and makes use of a mixed method approach to measure human subjectivity with the help of a participatory policy instrument, the Q-methodology. A total of 28 participants contributed to the results of this research. The Q-sorting consisted of a Q-sample of 40 statements, which was collected online with the use of the Q-sortware software. The Q-analysis of the collected data resulted in five social perspectives, which are categorized as; Team Players, Growth Seekers, Neutralists, Innovation Enthusiasts, Innovation Sceptics, and Innovators. At the end, the results conclude that a possible synergy between the creative industry and knowledge economy could thrive through a Citizen-centered Living Lab Quadruple Helix Innovation Model in the future, however, effective policy measures will be necessary to see this through.